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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Dosage Regimens: Designs and Approaches01:28

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
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The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
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Bimodal Programming: A Survey of Current Clinical Practice.

Hannah W Siburt, Alice E Holmes

    American Journal of Audiology
    |April 25, 2015
    PubMed
    Summary

    Clinical practices for bimodal programming in cochlear implant (CI) users show significant variability. This study reveals inconsistencies in hearing aid programming methods and personnel, highlighting a need for standardized approaches.

    Area of Science:

    • Audiology
    • Otorhinolaryngology
    • Biomedical Engineering

    Background:

    • Bimodal stimulation, combining a cochlear implant (CI) with a contralateral hearing aid, is increasingly common.
    • Standardized clinical protocols for bimodal programming are lacking.

    Purpose of the Study:

    • To investigate current clinical practices for bimodal programming in the United States.
    • To identify who programs hearing aids in bimodal configurations and the methods employed.

    Main Methods:

    • An 11-question online survey was distributed to 360 cochlear implant programming centers across the US.
    • The survey assessed practices related to hearing aid programming in bimodal conditions.

    Main Results:

    • A 26% response rate yielded diverse clinical settings.

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  • Significant disagreement exists regarding the programming of contralateral hearing aids in bimodal setups.
  • Smaller implant centers were less likely to recommend contralateral devices.

    • Conclusions:

    • Current clinical approaches to bimodal programming exhibit considerable inconsistency.
    • There is a clear need for more structured clinical recommendations and programming strategies for bimodal users.