Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world evidence of chemotherapy effects in advanced pancreatic ductal adenocarcinoma: prognostic significance of <i>TP53</i> status in gemcitabine plus nab-paclitaxel therapy.

ESMO gastrointestinal oncology·2026

Same author

Relationship between earlier introduction of tocilizumab and glucocorticoid-sparing effects on the acute phase of adult-onset Still's disease.

Scandinavian journal of rheumatology·2024

Same author

Resolution of exacerbated rheumatoid arthritis-associated interstitial lung disease under baricitinib treatment.

Scandinavian journal of rheumatology·2023

Same author

Efficacy and safety of plasma exchange in interstitial lung diseases with anti-melanoma differentiation-associated 5 gene antibody positive clinically amyopathic dermatomyositis.

Scandinavian journal of rheumatology·2021

Same author

Orbital apex syndrome on initial presentation of giant cell arteritis: a case report and review of the literature.

Scandinavian journal of rheumatology·2021

Same author

Gamma-Ray Observation of the Cygnus Region in the 100-TeV Energy Region.

Physical review letters·2021

Search research articles

Related Experiment Video

Updated: Apr 14, 2026

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Published on: May 10, 2021

Cholestatic Liver Injury After Biliary Reconstruction Impairs Transplanted Islet Viability and Function.

T Hata¹, N Sakata¹, G Yoshimatsu¹

¹Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|April 25, 2015

Summary

This summary is machine-generated.

Following total pancreatectomy with islet autotransplantation, cholestatic liver injury impairs transplanted islet viability and function due to increased oxidative stress. Intensive patient management is crucial to preserve islet health post-surgery.

Keywords:

Animal models: murine, complication islets of Langerhans liver (native) function/dysfunction

More Related Videos

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

Related Experiment Videos

Last Updated: Apr 14, 2026

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Published on: May 10, 2021

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

Area of Science:

Transplantation immunology
Hepatology
Endocrinology

Background:

Islet autotransplantation after pancreatectomy requires biliary reconstruction, potentially causing cholestatic liver injury.
The impact of this injury on transplanted islet viability and function remains unclear.

Purpose of the Study:

To investigate the effects of postoperative cholestatic liver injury on transplanted islet viability and function in a murine model.

Main Methods:

Developed a murine model involving syngeneic intraportal islet transplantation into diabetic mice with common bile duct ligation.
Assessed transplanted islet viability, function, and oxidative stress markers.

Main Results:

Common bile duct ligation led to impaired islet viability and function, evidenced by increased blood glucose levels.
Transplanted islets showed earlier signs of damage and higher oxidative stress marker expression compared to surrounding liver tissue.

Conclusions:

Transplanted islets are more susceptible to oxidative stress from cholestatic liver injury than liver tissue.
Intensive management is recommended post-total pancreatectomy with islet autotransplantation to maintain islet viability and function.