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Updated: Apr 14, 2026

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
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High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch.

Jingjiang Xu1, Xiaoming Wei1, Luoqin Yu1

  • 1Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

Biomedical Optics Express
|April 25, 2015
PubMed
Summary

This study introduces a new amplified optical time-stretch OCT (AOT-OCT) system achieving an 11.5 MHz A-scan rate. This breakthrough enables real-time, high-resolution 3D imaging of biological tissues at unprecedented speeds.

Keywords:
(110.4500) Optical coherence tomography(120.3180) Interferometry(170.3880) Medical and biological imaging

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Optical Coherence Tomography

Background:

  • High-speed volumetric imaging is crucial for real-time structural and functional tissue analysis.
  • Scaling Optical Coherence Tomography (OCT) beyond MHz A-scan rates is a key development goal.
  • Amplified Optical Time-Stretch OCT (AOT-OCT) offers a mechanical-tuning-free alternative for ultrafast OCT.

Purpose of the Study:

  • To develop and demonstrate a next-generation AOT-OCT system with enhanced performance.
  • To achieve single-shot A-scan rates exceeding 10 MHz for volumetric OCT imaging.
  • To evaluate the system's capabilities for high-speed biological tissue imaging.

Main Methods:

  • Utilized a stable, broadband, compact mode-locked fiber laser.
  • Integrated optical amplification within the time-stretch process.
  • Implemented a novel AOT-OCT architecture for enhanced data acquisition.

Main Results:

  • Achieved a superior A-scan rate of 11.5 MHz, surpassing previous time-stretch OCT modalities.
  • Demonstrated high shot-to-shot stability and sensitivity (~90dB).
  • Exhibited excellent roll-off performance (>4 mm/dB).

Conclusions:

  • The new AOT-OCT system provides superior performance for ultrafast OCT.
  • Enables the first volumetric time-stretch-based OCT of biological tissues at >10 MHz single-shot A-scan rate.
  • Presents a promising inertia-free solution for high-performance 3D OCT imaging at video rates.