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Apparent inosine uptake by the human heart.

J W de Jong¹, W Czarnecki, W Ruzyllo

¹Cardiochemical Laboratory, Erasmus University Rotterdam, The Netherlands.

Cardiovascular Research

|June 1, 1989

Summary

Exogenous inosine is taken up by the human heart, as shown by increased arterial concentrations during infusion. This inosine uptake correlated with improved cardiac function, specifically left ventricular dP/dtmax.

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Area of Science:

Cardiology
Pharmacology
Human Physiology

Background:

Inosine is clinically used for myocardial support.
Limited data exist on exogenous inosine's fate in the human heart.

Purpose of the Study:

To investigate the uptake and effects of exogenous inosine in the human heart.
To determine if inosine infusion impacts cardiac hemodynamics.

Main Methods:

Six patients undergoing coronary angiography received intravenous inosine infusion (5 mg.kg-1.min-1 for 6 minutes).
Arterial and coronary sinus blood samples were analyzed for inosine, hypoxanthine, and xanthine.
Left ventricular dP/dtmax was measured to assess cardiac function.

Main Results:

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Arterial inosine levels significantly increased during infusion, exceeding coronary sinus concentrations.
Elevated arterial hypoxanthine and xanthine levels were observed, indicating metabolic processing.
Left ventricular dP/dtmax increased by 22% post-infusion, suggesting improved myocardial contractility.

Conclusions:

The human heart substantially uptakes exogenous inosine.
Inosine administration leads to improved cardiac hemodynamics.
Further research into inosine's therapeutic potential for cardiac conditions is warranted.