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Topical agents for root caries prevention.

Martina Hayes1

  • 1Cork University Dental School and Hospital, Wilton, Cork, Ireland.

Evidence-Based Dentistry
|April 25, 2015
PubMed
Summary
This summary is machine-generated.

High-concentration fluoride (5,000 ppm F-) dentifrices and professionally applied chlorhexidine (CHX) or silver diamine fluoride (SDF) varnishes show promise for managing root caries (RCLs). However, evidence quality is limited, necessitating cautious interpretation of these preventive strategies.

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Area of Science:

  • Dental Public Health
  • Cariology
  • Preventive Dentistry

Background:

  • Root caries (RCLs) pose a significant challenge, particularly in aging populations.
  • Effective preventive strategies are crucial for managing and reducing the incidence of root caries.

Purpose of the Study:

  • To systematically evaluate the efficacy of various preventive agents in managing root caries.
  • To compare the effectiveness of different fluoride concentrations, combinations, and other agents in preventing and treating root caries.

Main Methods:

  • A systematic review and random-effects meta-analysis of randomized and non-randomized controlled trials.
  • Searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for English or German language studies.
  • Assessed study quality using the Cochrane risk of bias tool and evidence grading with GRADE.

Main Results:

  • High-concentration 5,000 ppm F- dentifrices demonstrated significant efficacy in inactivating RCLs (high evidence).
  • 1.5% arginine plus 1,450 ppm F- dentifrices showed some effect (very low evidence).
  • Professionally applied chlorhexidine (CHX) or silver diamine fluoride (SDF) varnishes significantly reduced root caries index (RCI) (very low evidence).

Conclusions:

  • Dentifrices with 5,000 ppm F- and professionally applied CHX or SDF varnishes may effectively inactivate existing RCLs and reduce new lesions.
  • Caution is advised due to the limited number of trials, high risk of bias in included studies, and low overall grade of evidence.