Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

141
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
141
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

180
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
180
Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

1.3K
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
1.3K
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

255
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
255
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

140
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
140
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

197
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
197

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Solvatochromic-Chemometric Framework to Resolve Subtle Polarity Microenvironment Differences in Cycloalkanes Driven by Molecular Conformation and Substituent Effects: A Proof-Of-Concept for Advanced Aviation Fuel Design.

The journal of physical chemistry. B·2026
Same author

A smart ingestible capsule for real-time monitoring of stimuli-responsive polymer dissolution kinetics and oral drug release in the gastrointestinal tract.

Biosensors & bioelectronics·2026
Same author

Detection to Disruption: A Comprehensive Review of Bacterial Biofilms and Therapeutic Advances.

Antibiotics (Basel, Switzerland)·2026
Same author

From materials to systems: recent advances on electrochemical sensors for capsaicin detection.

The Analyst·2026
Same author

Subunit-specific interfacial adaptability of x-type HMW-GS revealed by molecular dynamics and linked to dough fermentation performance.

Food chemistry·2026
Same author

Cold Atmospheric Plasma-Assisted Deposition of SiOx-Ag Nanocomposites for SERS-Based Detection of <i>Listeria monocytogenes</i> in Complex Food Matrices.

Sensors and actuators. B, Chemical·2026
Same journal

Assessment of skin stiffness in systemic sclerosis using optical coherence elastography: A comparative study with histology and clinical parameters.

IEEE transactions on bio-medical engineering·2026
Same journal

Modeling Dyadic Interdependence in Endocrine Functioning: A Multilevel Machine Learning Study of Adults with Cancer and Their Caregivers.

IEEE transactions on bio-medical engineering·2026
Same journal

A Kalman Filter-Based Framework for Granger Causality Assessment: Application in Tracking Maternal-Fetal Heart Rate Coupling.

IEEE transactions on bio-medical engineering·2026
Same journal

Enhancing Volumetric Imaging in Linear-Array Photoacoustic Tomography: multiview fusion with deep learning.

IEEE transactions on bio-medical engineering·2026
Same journal

Robust Rule-based Heuristic Assistance Strategy for a Semi-Active Shoulder Exoskeleton Used in Overhead Work.

IEEE transactions on bio-medical engineering·2026
Same journal

Highly Accelerated 1-mm Isotropic 3D Chemical Exchange Saturation Transfer MRI Using Wave-Co-CAIPI at 5 Tesla.

IEEE transactions on bio-medical engineering·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

9.0K

A Smart Capsule With GI-Tract-Location-Specific Payload Release.

Wuyang Yu, Rahim Rahimi, Manuel Ochoa

    IEEE Transactions on Bio-Medical Engineering
    |April 25, 2015
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a smart capsule for targeted drug delivery in the gastrointestinal tract. Activated by magnets, it precisely releases medication at a specific location, improving therapeutic outcomes.

    More Related Videos

    Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
    10:07

    Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

    Published on: October 8, 2021

    1.8K
    Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
    09:02

    Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

    Published on: September 27, 2024

    3.2K

    Related Experiment Videos

    Last Updated: Apr 14, 2026

    Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
    08:17

    Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

    Published on: September 27, 2018

    9.0K
    Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
    10:07

    Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

    Published on: October 8, 2021

    1.8K
    Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
    09:02

    Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

    Published on: September 27, 2024

    3.2K

    Area of Science:

    • Biomedical Engineering
    • Gastroenterology
    • Drug Delivery Systems

    Background:

    • Current drug delivery methods often lack precise control over release location within the gastrointestinal tract.
    • Targeted drug release can enhance therapeutic efficacy and reduce systemic side effects.

    Purpose of the Study:

    • To develop and demonstrate a smart capsule capable of location-specific drug release in the gastrointestinal tract.
    • To enable precise drug delivery using magnetic activation and a novel release mechanism.

    Main Methods:

    • A smart capsule (9 mm x 26 mm) with two compartments was designed.
    • One compartment housed a charged capacitor and reed switch; the second contained the drug reservoir.
    • A nylon thread with an integrated nichrome wire secured the reservoir cap, connected to the capacitor via the reed switch.

    Main Results:

    • The capsule successfully released its powdered payload upon magnetic activation.
    • Proximity to a magnetic marker (implanted or external) triggered the reed switch.
    • The capacitor discharged, melting the nichrome wire, breaking the nylon thread, and releasing the drug.

    Conclusions:

    • The developed smart capsule offers a viable solution for location-specific drug delivery in the GI tract.
    • Magnetic activation provides a reliable trigger for controlled drug release.
    • This technology has the potential to significantly advance targeted gastrointestinal therapies.