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Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis
Andrew M Rosen1, Timothy Spellman2, Joshua A Gordon3
1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.
Abstract:
Schizophrenia is caused by a diverse array of risk factors and results in a similarly diverse set of symptoms. Electrophysiological endophenotypes lie between risks and symptoms and have the potential to link the two. Electrophysiological studies in rodent models, described here, demonstrate that widely differing risk factors result in a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared neurobiological substrate.
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