Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.4K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Tooth Anatomy01:21

Tooth Anatomy

3.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
3.0K
Neurulation01:30

Neurulation

47.6K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.6K
Teeth01:15

Teeth

2.3K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
2.3K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

39.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
39.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HED-Derived iPSCs Reveal Neurofunctional Defects in Ectodermal Dysplasia.

Journal of dental research·2026
Same author

Hierarchical reinforcement strategy enables aluminum matrix composites with uncompromised high-temperature mechanical properties.

Nature communications·2026
Same author

[Review of oral genetic diseases in China].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025
Same author

Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial.

JDR clinical and translational research·2025
Same author

Research on the relative humidity changes of the controlled atmosphere environment for redried tobacco storage.

Scientific reports·2025
Same author

Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 14, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.8K

The Gene Network Underlying Hypodontia.

W Yin1, Z Bian2

  • 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China Department of Endodontics & Periodontics, College of Stomatology, Dalian Medical University, Dalian, China.

Journal of Dental Research
|April 26, 2015
PubMed
Summary
This summary is machine-generated.

Understanding genes involved in tooth agenesis is crucial for developing new treatments. This review highlights key genes and pathways regulating tooth development to improve patient outcomes.

Keywords:
EDA geneMSX1 genePAX9 genegenotypephenotypesignal pathway

More Related Videos

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.7K

Related Experiment Videos

Last Updated: Apr 14, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.8K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

8.7K

Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Mammalian tooth development involves complex signaling pathways, including nuclear factor kappa B (NF-κB) and WNT.
  • Disturbances in these pathways are linked to tooth agenesis, with over 150 syndromes and 80 genes identified.
  • Understanding gene interactions is vital for elucidating the mechanisms behind missing teeth.

Purpose of the Study:

  • To review recent findings on genes associated with isolated and syndromic tooth agenesis.
  • To explore the molecular networks and signaling pathways involved in tooth agenesis.
  • To discuss the clinical implications of these genetic factors for patient management.

Main Methods:

  • Literature review of recently published studies on tooth agenesis.
  • Analysis of gene functions, focusing on cell proliferation, differentiation, and apoptosis.
  • Exploration of gene interaction networks and signaling pathways.

Main Results:

  • Most genes implicated in tooth agenesis act as positive regulators of cell proliferation or negative regulators of cell differentiation and apoptosis.
  • Identified key signaling pathways and gene networks underlying tooth agenesis.
  • Highlighted the roles of specific genes in both isolated and syndromic forms of tooth agenesis.

Conclusions:

  • Further research into gene interactions and signaling pathways is necessary for a comprehensive understanding of tooth agenesis.
  • Elucidating these mechanisms can lead to improved diagnostic and therapeutic strategies.
  • Enhanced knowledge will ultimately improve the quality of life for patients with tooth agenesis.