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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
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Biomarkers in acute heart failure.
Aditi Mallick1, James L Januzzi2
1Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Revista Espanola De Cardiologia (English Ed.)
|April 26, 2015
Summary
Established and novel biomarkers, including B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide, are improving the diagnosis, prognosis, and management of acute decompensated heart failure.
Area of Science:
- Cardiology
- Biomarker Discovery
- Clinical Diagnostics
Background:
- Acute decompensated heart failure (ADHF) care is evolving with new biomarkers.
- B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are established ADHF biomarkers.
- Emerging biomarkers offer enhanced diagnostic and prognostic capabilities for ADHF.
Purpose of the Study:
- To review the pathophysiology and clinical utility of established and novel biomarkers in ADHF.
- To highlight biomarkers aiding in ADHF diagnosis, prognosis, and management.
- To discuss biomarkers for differential diagnosis of dyspnea and prediction of complications in ADHF.
Main Methods:
- Review of established and emerging heart failure biomarkers.
- Discussion of biomarkers involved in myocardial injury, neurohormonal activation, and ventricular remodeling.
- Examination of biomarkers for dyspnea differential diagnosis and complication prediction.
Main Results:
- BNP and NT-proBNP are crucial for ADHF diagnosis, prognosis, and management.
- Novel biomarkers like midregional proatrial natriuretic peptide, soluble ST2, galectin-3, high-sensitivity troponin, and midregional proadrenomedullin show promise.
- Biomarkers such as procalcitonin and renal injury markers assist in differential diagnosis and complication prediction.
Conclusions:
- Established and novel biomarkers significantly enhance ADHF patient care.
- Understanding these biomarkers improves diagnostic accuracy and prognostic assessment in ADHF.
- Biomarker-guided strategies are essential for optimizing ADHF management and predicting outcomes.
Keywords:
Acute decompensated heart failureBiomarcadoresBiomarkersInsuficiencia cardiaca aguda descompensadaMore Related Videos
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