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Related Experiment Video

Updated: Apr 14, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Candida survival strategies.

Melanie Polke¹, Bernhard Hube², Ilse D Jacobsen³

¹Research Group Microbial Immunology, Hans-Knoell-Institute, Jena, Germany; Department Microbial Pathogenicity Mechanisms, Hans-Knoell-Institute, Jena, Germany.

Advances in Applied Microbiology

|April 26, 2015

Summary

Certain Candida species, like Candida albicans, can colonize humans and cause infections. Their adaptability, biofilm formation, and interactions with bacteria are key survival strategies.

Keywords:

Adhesion Biofilm C. albicans Immune evasion Invasion Morphology Polymicrobial Quorum sensing Stress resistance Survival

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A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

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Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host

Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host

Published on: October 12, 2022

Area of Science:

Mycology
Infectious Diseases
Microbiology

Background:

Candida species are successful human colonizers, causing infections from superficial to life-threatening disseminated disease.
Candida albicans, the most prevalent species, exhibits remarkable flexibility for adapting to diverse host niches.
Candida survival is influenced by biofilm formation and interactions with the human microbiome.

Purpose of the Study:

To review current knowledge on Candida survival strategies.
To focus on fitness and virulence traits of Candida albicans.
To understand the impact of fungal-bacterial interactions on Candida colonization and disease.

Main Methods:

Literature review of current knowledge on Candida spp.
Focus on genetic, biochemical, and morphological flexibility of Candida albicans.
Analysis of biofilm formation and fungal-bacterial interactions.

Main Results:

Candida albicans' success relies on its adaptability, biofilm production, and interactions with host microbes.
These strategies enable Candida to thrive in various host environments and cause disease.
Fungal-bacterial interactions significantly impact Candida's commensal role and pathogenicity.

Conclusions:

Candida spp. possess sophisticated survival mechanisms enabling colonization and infection.
Understanding Candida's fitness and virulence traits is crucial for managing candidiasis.
Further research into fungal-bacterial interactions can reveal new therapeutic targets.