Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulse oximetry in sickle cell disease.

S G Weston Smith1, U H Glass, J Acharya

  • 1Division of Haematology, United Medical School, Guy's Hospital, St Thomas's Hospital, London.

Clinical and Laboratory Haematology
|January 1, 1989
PubMed
Summary

Pulse oximetry accurately monitors arterial oxygen saturation in sickle cell disease patients. This non-invasive method provides reliable readings, unlike standard blood gas analysis assuming a normal oxygen dissociation curve.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

N-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats.

Toxicology research·2025
Same author

Saree on Fireside: Fatal Burn in an Elderly Nepalese Female.

Kathmandu University medical journal (KUMJ)·2022
Same author

Complications of Radiotherapy and Radiosurgery in the Brain and Spine.

Neurographics (2011)·2022
Same author

Prevalence of Loss of Smell and/or Taste and other Otorhinolaryngology Symptoms in COVID-19 Patients.

Kathmandu University medical journal (KUMJ)·2021
Same author

Effect of Planting into a Green Winter Cereal Rye Cover Crop on Growth and Development, Seedling Disease, and Yield of Corn.

Plant disease·2021
Same author

Improved Glioma Grading Using Deep Convolutional Neural Networks.

AJNR. American journal of neuroradiology·2020

Area of Science:

  • Hematology
  • Medical Devices
  • Pulmonary Medicine

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder requiring careful monitoring of oxygenation.
  • Accurate assessment of arterial oxygen saturation is crucial for managing SCD complications.
  • Traditional methods like arterial blood gas analysis can be invasive and time-consuming.

Purpose of the Study:

  • To evaluate the efficacy of pulse oximetry for monitoring arterial oxygen saturation in patients with sickle cell anemia.
  • To compare pulse oximetry readings with simultaneous arterial blood gas measurements and oxygen dissociation curve (ODC) analysis.
  • To determine if pulse oximetry is a reliable non-invasive tool for SCD management.

Main Methods:

  • A comparative study involving four admissions of sickle cell anemia patients with varying degrees of hypoxemia.

Related Experiment Videos

  • Simultaneous measurement of arterial oxygen saturation using pulse oximetry and arterial blood gas analysis.
  • Oxygen saturation was calculated from PaO2 using the patient's individual oxygen dissociation curve (ODC).

    • Main Results:

    • Pulse oximetry demonstrated close agreement with oxygen saturation values derived from arterial blood gas measurements and patient-specific ODC.
    • Blood gas analyzer calculations assuming a normal ODC yielded erroneous oxygen saturation results.
    • The study confirmed the accuracy of pulse oximetry in the context of SCD.

    Conclusions:

    • Pulse oximetry is an accurate and effective non-invasive method for monitoring arterial oxygen saturation in sickle cell disease.
    • It offers a reliable alternative to invasive blood gas measurements, especially when considering individual ODC variations.
    • This technology can improve the clinical management and monitoring of patients with SCD.