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Published on: February 3, 2012
[Chronic hepatitis C--clinical and autonomic characteristics]
Insights
This study reveals that patients with chronic hepatitis C and viral liver cirrhosis exhibit heightened sympathetic nervous system activity and reduced parasympathetic activity. These autonomic nervous system imbalances indicate significant adaptation issues in these patients.
Area of Science:
- Hepatology
- Autonomic Neuroscience
- Cardiology
Abstract:
The article presents the results of a survey of 62 patients with chronic hepatitis C and 103 patients with liver cirrhosis of viral etiology. Besides clinical parameters studied autonomic features by analysis of heart rate variability at rest and active orthostasis. Indicators of frequency and spectral analysis of heart rate in study patients with chronic hepatitis C and cirrhosis of viral etiology confirmed increase in sympathetic activity and weakening of parasympathetic activity in all respects, with the sympathetic influence of enhanced active orthostasis. Indices of regulatory systems of the autonomic nervous system (stress index and the index of autonomic regulation) also indicated a statistically significant predominance sympathicotonia at rest and active orthostasis, indicating serious violations of adaptation in the examinees.
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