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Updated: Apr 14, 2026
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Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
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Olanzapine-induced Orthostatic Hypotension.
Amlan Kusum Jana1, Samir Kumar Praharaj2, Nirmalya Roy1
1Department of Psychiatry, KPC Medical College and Hospital, Kolkata, West Bengal.
Summary
Olanzapine, an antipsychotic for schizophrenia, can cause dose-dependent orthostatic hypotension. This side effect is less common but should be monitored in patients, especially at higher doses.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Medicine
Background:
- Olanzapine is an effective atypical antipsychotic for schizophrenia treatment.
- Its adverse effect profile is generally favorable, with metabolic events being a notable exception.
- Orthostatic hypotension is infrequently associated with olanzapine compared to other antipsychotics.
Purpose of the Study:
- To report a rare case of olanzapine-induced orthostatic hypotension.
- To investigate the dose-dependent relationship between olanzapine and postural hypotension.
Main Methods:
- Case report detailing a patient's experience with olanzapine.
- Clinical observation of blood pressure changes in relation to olanzapine dosage.
Main Results:
- The patient experienced transient postural hypotension.
- The hypotension was observed to be dose-dependent, worsening with increased olanzapine levels.
Conclusions:
- Olanzapine can cause dose-dependent transient postural hypotension, although it is uncommon.
- Clinicians should be aware of this potential adverse effect, even with atypical antipsychotics.
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