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Effect of respiration on heartbeat-evoked potentials during sleep in children with sleep-disordered breathing

Mathias Baumert1, Yvonne Pamula2, Mark Kohler3

  • 1School of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.

Sleep Medicine
|April 28, 2015
PubMed

Insights

In children with sleep-disordered breathing (SDB), heartbeat-evoked potentials (HEPs) are reduced during expiration, indicating impaired cardiac awareness. Treatment improved this, linking breathing and cardiac processing.

Area of Science:

  • Neuroscience
  • Cardiology
  • Sleep Medicine

Background:

  • Heartbeat-evoked potentials (HEPs) quantify cardiac interoception during sleep.
  • Previous studies showed reduced HEPs in children with sleep-disordered breathing (SDB).

Purpose of the Study:

  • To investigate the relationship between HEPs and respiration in children.
  • To explore the link between cardiac interoception and breathing patterns in SDB.

Main Methods:

  • Overnight polysomnograms from 40 healthy children and 40 with SDB were analyzed.
  • HEPs were measured during specific sleep stages, considering respiratory phase.

Main Results:

  • A significant association between respiratory phase and HEPs was found in children with SDB during REM sleep.
  • HEPs were attenuated during expiration compared to inspiration in SDB children.
  • Adenotonsillectomy normalized expiratory HEP amplitude in SDB children.

Conclusions:

  • The expiratory phase of respiration is linked to attenuated cardiac information processing in children with SDB.
  • This establishes a pathophysiological connection between breathing and HEP attenuation in SDB.
Abstract

Keywords:
ChildrenHeartbeat-evoked potentialsRespirationSleep-disordered breathing

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