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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Venous Thromboembolism after Allogeneic Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Study

Fatih Azık, Dilek Gürlek Gökçebay, Betül Tavil

    Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology
    |April 28, 2015
    PubMed

    Insights

    Venous thromboembolism (VTE) is uncommon in pediatric hematopoietic stem cell transplant (HSCT) recipients. Inherited risk factors did not significantly correlate with VTE events in this study.

    Area of Science:

    • Hematology
    • Pediatric Oncology
    • Transplantation Medicine

    Background:

    • Venous thromboembolism (VTE) presents significant morbidity in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT).
    • Assessing pretransplant prothrombotic risk factors is crucial for understanding thrombosis in this vulnerable population.

    Purpose of the Study:

    • To determine the incidence of VTE in pediatric allogeneic HSCT recipients.
    • To evaluate the contribution of inherited and acquired prothrombotic risk factors to the development of VTE post-HSCT.

    Main Methods:

    • Retrospective analysis of 92 pediatric patients undergoing allogeneic HSCT.
    • Screening for inherited thrombophilia (Factor V Leiden, Prothrombin G20210A, MTHFR mutations) and acquired risk factors prior to HSCT.
    • Monitoring for VTE events within 100 days post-HSCT.

    Main Results:

    • The incidence of VTE was 5.4% (5 out of 92 patients).
    • A prothrombotic risk factor was identified in 3 VTE cases, and central venous catheters were present in 4 cases.
    • No significant association was found between VTE and inherited prothrombotic risk factors.

    Conclusions:

    • VTE appears to be a low-frequency complication following pediatric HSCT.
    • Low-molecular-weight heparin prophylaxis may contribute to the low VTE rate.
    • Further prospective studies are needed to fully elucidate the role of inherited prothrombotic risk factors.
    Abstract

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