Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

3.1K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
3.1K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
Neural Regulation01:37

Neural Regulation

45.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.1K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.6K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin E nomenclature: Summary and response to articles published in the FRBM Vitamin E Discussion Forum.

Free radical biology & medicine·2025
Same author

Antioxidant-independent activities of alpha-tocopherol.

The Journal of biological chemistry·2025
Same author

Vitamin E discussion forum position paper on the revision of the nomenclature of vitamin E.

Free radical biology & medicine·2023
Same author

Adenovirus Reveals New Pathway for Cholesterol Egress from the Endolysosomal System.

International journal of molecular sciences·2020
Same author

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.

Cell death & disease·2020
Same author

Vitamin E sequestration by liver fat in humans.

JCI insight·2019

Related Experiment Video

Updated: Apr 14, 2026

Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

40.0K

Vitamin E and neurodegeneration.

Lynn M Ulatowski1, Danny Manor1

  • 1Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Neurobiology of Disease
|April 28, 2015
PubMed
Summary
This summary is machine-generated.

Alpha-tocopherol (vitamin E) is a vital antioxidant protecting the brain from oxidative damage. Adequate vitamin E intake is crucial for cerebellar function, learning, memory, and potentially other neurological disorders.

Keywords:
AnxietyCerebellumMemoryNeurodegenerationTocopherolVitamin E

More Related Videos

Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.6K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.6K

Related Experiment Videos

Last Updated: Apr 14, 2026

Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

40.0K
Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.6K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.6K

Area of Science:

  • Neuroscience
  • Nutritional Science
  • Biochemistry

Background:

  • Alpha-tocopherol, a form of vitamin E, is a potent antioxidant crucial for human health.
  • Vitamin E deficiency is linked to central nervous system damage, particularly in the cerebellum, causing motor deficits.

Purpose of the Study:

  • To review the established neuroprotective roles of vitamin E in the cerebellum.
  • To highlight emerging evidence on vitamin E's role in cognitive and emotional functions.
  • To discuss the relevance of vitamin E adequacy in various neurological conditions.

Main Methods:

  • Literature review of human and animal studies.
  • Analysis of research on oxidative stress and neurological function.
  • Synthesis of data on alpha-tocopherol's impact on the central nervous system.

Main Results:

  • Vitamin E is essential for protecting the cerebellum from oxidative stress and maintaining motor coordination.
  • Emerging research indicates vitamin E's critical role in learning, memory, and emotional responses.
  • Vitamin E adequacy may influence outcomes in neurological disorders beyond direct cerebellar effects.

Conclusions:

  • Vitamin E plays a fundamental role in maintaining cerebellar health and cognitive functions.
  • Ensuring adequate vitamin E levels is important for overall neurological well-being.
  • Further research is warranted to explore vitamin E's therapeutic potential in diverse neurological disorders.