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Sandensone A, a novel sesquiterpenoid from the Formosan soft coral Sinularia sandensis
Shi-Yie Cheng1, Shang-Kwei Wang2, Pei-Wen Chen3
1Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
Abstract:
A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the soft coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher's method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro.