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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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ClosIndb: A resource for computationally derived information from clostridial genomes.

Raja Polavarapu¹, Potshangbam Angamba Meetei¹, Mohit Midha¹

¹Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases

|April 28, 2015

Summary

Researchers analyzed clostridial genomes, developing ClosIndb, a web resource detailing gene information. This database aids comparative genomics and future clostridial research.

Keywords:

Clostridium Motifs Operons Orthologs

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Area of Science:

Genomics
Bioinformatics
Microbial research

Background:

Numerous clostridial genomes have been sequenced, with 49 species' complete genomes available.
This genomic data offers significant potential for advancing clostridial research.

Purpose of the Study:

To perform in silico analysis of available clostridial genomic data.
To develop a comprehensive web resource, ClosIndb, for accessing and analyzing clostridial gene information.

Main Methods:

In silico analysis of sequenced clostridial genomes.
Development of the ClosIndb web resource to collate and present genomic data.
Inclusion of coding and non-coding region information, including orthologs, protein properties, operons, and cis-regulatory elements.

Main Results:

ClosIndb provides a centralized repository of computational information for all clostridial genes.
The resource facilitates comparative analysis of clostridial proteins across Firmicutes.
It includes data on coding regions, non-coding regions, putative orthologs, protein physicochemical properties, operons, and cis-regulatory elements.

Conclusions:

ClosIndb is a valuable and comprehensive resource for researchers studying completely sequenced clostridial genomes.
The database is continuously updated and freely accessible, supporting ongoing clostridial research.
This resource aids in unraveling the genomic potential of Clostridia.