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Urinary elastase 1 in chronic pancreatic disease.
1Istituto di Medicina Interna, Università degli Studi di Verona, Italia.
Enzyme
|January 1, 1989
Summary
Increased urinary elastase 1 output occurs in some patients with chronic pancreatic disease. Renal tubular damage, not just enzyme levels, significantly impacts this increased elastase 1 excretion.
Area of Science:
- Biochemistry
- Nephrology
- Gastroenterology
Background:
- Pancreatic elastase 1 plays a role in digestion.
- Altered elastase 1 levels are observed in pancreatic diseases.
- Understanding plasma-urine transfer is crucial for disease assessment.
Purpose of the Study:
- To evaluate elastase 1 plasma-urine transfer in chronic pancreatic diseases.
- To investigate factors influencing elastase 1 clearance.
- To correlate urinary enzyme excretion with pancreatic conditions.
Main Methods:
- Measured serum and urine elastase 1, gamma-glutamyltransferase, and ribonuclease.
- Analyzed renal output and clearance of elastase 1.
- Assessed serum elastase 1 molecular size distribution via chromatography.
Main Results:
- Increased urinary elastase 1 output observed in patients with pancreatic cancer and chronic pancreatitis.
- No correlation between circulating elastase 1 and urinary output.
- Negative correlation between serum elastase 1 levels and its clearance.
- Urinary ribonuclease and gamma-glutamyltransferase correlated with elastase 1 parameters.
- Renal tubular damage identified as a key factor in increased urinary elastase 1.
Conclusions:
- Urinary elastase 1 excretion can increase in chronic pancreatic disease, irrespective of cause (neoplastic or inflammatory).
- Renal tubular damage is a significant factor influencing increased urinary elastase 1 output.
- Ultrafiltrable enzyme availability may influence plasma-urine transfer, but tubular function is paramount.