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Related Experiment Video

Updated: Apr 14, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

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Repeat radiosurgery for cerebral arteriovenous malformations.

Ahmed J Awad1, Brian P Walcott2, Christopher J Stapleton2

  • 1Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|April 28, 2015
PubMed
Summary

Repeat radiosurgery for cerebral arteriovenous malformations (AVM) achieves a 61% obliteration rate. Complications include hemorrhage and radiation changes, with repeat treatment considered 3 years after initial therapy.

Keywords:
Arteriovenous malformationGamma knifeLINACNeurosurgeryRetreatmentStereotactic radiosurgery

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Systematic Review

Background:

  • Cerebral arteriovenous malformations (AVM) require effective treatment to prevent hemorrhage.
  • Radiosurgery is a key modality for AVM in eloquent or deep brain regions.
  • Repeat radiosurgery is an option for residual AVM after initial treatment.

Purpose of the Study:

  • To systematically review repeat radiosurgery for AVM.
  • To evaluate obliteration rates and complication profiles of repeat radiosurgery.
  • To establish optimal timing for repeat radiosurgery.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searches conducted on MEDLINE, Web of Science, and Google Scholar.
  • Inclusion of 14 studies with 733 patients.

Main Results:

  • Mean obliteration rate for repeat radiosurgery was 61% (95% CI 51.9-71.7%).
  • Median follow-up ranged from 19.5 to 80 months.
  • Common complications included hemorrhage (7.6%) and radiation-induced changes (7.4%).

Conclusions:

  • Repeat radiosurgery offers a 61% obliteration rate for incompletely treated AVM.
  • Complications are linked to hemorrhage risk and radiation effects.
  • Repeat treatment is advisable at least 3 years post-initial radiosurgery.