Memantine-associated hyperkalaemia in a patient with Alzheimer's disease
Tatsuo Tsukamoto1, Hidetaka Yamada, Naohisa Uchimura
1Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan; Department of Psychiatry, St. Maria Hospital, Kurume, Japan.
Abstract:
Memantine is an N-methyl-D-aspartate glutamate receptor antagonist that may improve cognitive functions in patients with Alzheimer's disease. It is predominantly excreted unchanged via the kidneys, and patients with decreased creatinine clearance must be treated with lower doses of memantine. However, it is unclear whether memantine itself can lead to renal dysfunction and/or hyperkalaemia. We report a patient with renal impairment and hyperkalaemia possibly associated with memantine administration.
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