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Updated: Apr 14, 2026
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Long-term outcomes after elective ileocecal resection in children with active localized Crohn's disease--a
Iva Hojsak1, Sanja Kolacek1, Lars Folmer Hansen2
1Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
Insights
Elective ileocecal resection offers a valid treatment for pediatric localized Crohn's disease, improving remission rates and growth. This surgery should be considered for select children to achieve clinical remission and enhance growth outcomes.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Inflammatory Bowel Disease
Background:
- Crohn's disease is a chronic inflammatory bowel disease affecting children.
- Localized ileocecal involvement is common in pediatric Crohn's disease.
- Surgical intervention, such as ileocecal resection, is considered for refractory or complicated cases.
Purpose of the Study:
- To evaluate the therapeutic role of elective ileocecal resection in children with active localized Crohn's disease.
- To assess the impact of surgery on clinical remission and growth in pediatric patients.
- To identify potential risk factors for postsurgical relapse.
Main Methods:
- Retrospective multicenter study involving five European referral centers.
- Inclusion of pediatric patients with Crohn's disease who underwent ileocecal surgery between 2000 and 2011.
- Minimum follow-up of 12 months postoperatively.
Main Results:
- 68 pediatric patients met the inclusion criteria.
- 79.4% achieved clinical remission one year after surgery, with a median remission duration of 20 months.
- Significant improvement in height-for-age Z-score was observed in patients younger than 16 years at surgery (p=0.029).
Conclusions:
- Elective ileocecal resection is a viable treatment option for select pediatric patients with localized Crohn's disease.
- The procedure can effectively induce clinical remission and promote growth.
- No significant risk factors for postsurgical relapse were identified in this cohort.
Purpose:
The aim of this study was to investigate the therapeutic role of an elective ileocecal resection in children with active localized Crohn's disease.
Methods:
This was a retrospective multicenter study which included five European referral centers which included all children with Crohn's disease who underwent ileocecal surgery from 2000 to 2011 and had a minimum of 12 months follow-up.
Results:
Altogether 68 patients fulfilled inclusion criteria. Median age at diagnosis was 13.7 years (6.6-17.9 years) and at surgery 15.2 years (8.6-18.5 years). Median duration of postoperative clinical remission was 20 months (3-95 months). Overall 54 patients (79.4%) were in remission one year after surgery and 38 (55.9%) during the total postsurgical follow up (median 30 months; range 12-95 months). Z score height for age significantly improved postoperatively in children who were at the time of surgery younger than 16 years of age (mean difference 0.232 SD; p=0.029). Cox proportional hazard regression model failed to indicate risk factors associated with postsurgical relapse.
Conclusion:
Elective ileocecal resection is a valid treatment option which should be considered in a subset of pediatric patients with localized Crohn's disease with the aim of achieving clinical remission and to improve growth.
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