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Published on: May 25, 2018
The history and market impact of CRISPR RNA-guided nucleases
Paul Bg van Erp1, Gary Bloomer2, Royce Wilkinson1
1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Abstract:
The interface between viruses and their hosts' are hot spots for biological and biotechnological innovation. Bacteria use restriction endonucleases to destroy invading DNA, and industry has exploited these enzymes for molecular cut-and-paste reactions that are central to many recombinant DNA technologies. Today, another class of nucleases central to adaptive immune systems that protect bacteria and archaea from invading viruses and plasmids are blazing a similar path from basic science to profound biomedical and industrial applications.
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