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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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992

Relationship between Serum Bilirubin and Left Ventricular Hypertrophy in Patients with Essential Hypertension

Tao Zhou1, Xiaofang Chen2, Zhanzhan Li3

  • 1Department of Cardiology, the Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.

Plos One
|April 28, 2015
PubMed

Insights

Lower serum bilirubin levels are linked to left ventricular hypertrophy (LVH) in new hypertension patients. This suggests bilirubin may serve as a novel risk marker for LVH in essential hypertension.

Area of Science:

  • Cardiology
  • Clinical Biochemistry

Background:

  • Prospective studies indicate low bilirubin levels predict cardiovascular events.
  • The association between serum bilirubin and left ventricular hypertrophy (LVH) in essential hypertension requires further investigation.

Purpose of the Study:

  • To evaluate the relationship between serum bilirubin levels and LVH in newly diagnosed hypertension patients.

Main Methods:

  • A study of 344 newly diagnosed hypertensive patients, divided into LVH (n=138) and non-LVH (n=206) groups.
  • Utilized physical examination, laboratory tests, and echocardiography.
  • Employed multivariate logistic regression to assess the association between serum bilirubin and LVH.

Main Results:

  • Patients with LVH exhibited lower serum bilirubin levels compared to those without LVH.
  • Serum total bilirubin showed a negative association with left ventricle mass index (LVMI) (B=-0.017, P=0.008), even after adjusting for confounders.
  • Serum total bilirubin was independently associated with LVH, acting as a protective factor (OR=0.91, P=0.010).

Conclusions:

  • Serum bilirubin may serve as a novel, readily available marker for assessing LVH risk in hypertensive individuals.
  • Further large-scale cohort studies are warranted to confirm these findings.
Abstract

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