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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Related Experiment Video

Updated: Apr 14, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

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Platelet interactions with viruses and parasites.

Ana Lopez Alonso1, Dermot Cox

  • 1Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland , Dublin , Ireland.

Platelets
|April 28, 2015
PubMed
Summary

Platelets interact with various pathogens, not just bacteria. Receptors like FcγRIIa and Toll-Like Receptors (TLR) are crucial in these interactions, which are important in infections like viral hemorrhagic fever.

Area of Science:

  • Immunology
  • Microbiology
  • Hematology

Background:

  • Platelet interactions with Gram-positive bacteria are well-documented.
  • Limited data exists on interactions between platelets and other pathogens.
  • Thrombocytopenia is common in infections, including viral hemorrhagic fever.

Purpose of the Study:

  • To review known interactions between platelets and various pathogens.
  • To highlight the role of specific receptors in these interactions.

Main Methods:

  • Literature review of studies on pathogen-platelet interactions.
  • Focus on viral, fungal, and parasitic pathogen interactions.

Main Results:

  • Platelet interactions with pathogens share similarities with bacteria-platelet interactions.
Keywords:
Fungiparasitesplateletsviruses

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  • FcγRIIa and Toll-Like Receptors (TLR) are key mediators in many pathogen-platelet interactions.

    • Conclusions:

    • Platelets play a significant role in the host response to a diverse range of pathogens.
    • Further research is needed to fully elucidate pathogen-platelet interactions beyond bacterial infections.