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Gamete intrafallopian transfer: benefits of programmed stimulation
1Service de Gynécologie et Obstétrique, Polyclinique Phillipe Marcombes, Centre Hospitalier et Universitaire, Clermont Ferrand, France.
Fertility and Sterility
|December 1, 1989
Summary
Gamete intrafallopian transfer (GIFT) cycles programmed with norethisterone showed a 41.1% implantation rate. This method resulted in a 30.4% evolutive pregnancy rate, with a notable decrease in preovulatory luteinizing hormone levels.
Area of Science:
- Reproductive Endocrinology
- Human Assisted Reproduction Technologies
Background:
- Gamete intrafallopian transfer (GIFT) is an assisted reproductive technology.
- Hormonal programming influences the success of GIFT cycles.
Purpose of the Study:
- To evaluate the efficacy and endocrinological impact of a GIFT protocol using norethisterone for cycle programming.
- To compare hormonal profiles with in vitro fertilization (IVF) protocols.
Main Methods:
- Fifty-six GIFT cycles were programmed using norethisterone.
- Ovarian hyperstimulation was induced with clomifene citrate and human menopausal gonadotropins.
- Hormonal levels, including serum luteinizing hormone (LH), were monitored.
Main Results:
- The implantation rate was 41.1% and the evolutive pregnancy rate was 30.4%.
- A significant decrease in preovulatory serum LH levels was observed.
- Only 1.8% of GIFT procedures were performed on a weekend.
Conclusions:
- Norethisterone programming for GIFT is associated with favorable implantation and pregnancy rates.
- The protocol leads to a suppressed preovulatory LH surge, which may impact outcomes.
- Further comparison with IVF endocrinology is warranted.