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HIV-1 and interferons: who's interfering with whom?

Tomas Doyle1, Caroline Goujon1, Michael H Malim1

  • 1Department of Infectious Diseases, King's College London, 2nd Floor, Borough Wing, Guy's Hospital, London Bridge, London SE1 9RT, UK.

Nature Reviews. Microbiology
|April 28, 2015
PubMed
Summary

Interferons (IFNs) can inhibit HIV-1 replication, but elevated levels in chronic infection correlate with disease progression. This review explores IFNs' dual role in controlling viral load and potentially exacerbating AIDS pathology.

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