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Large corneal grafts can be successful.
C M Kirkness1, L A Ficker, N S Rice
1Corneal Clinic, Moorfields Eye Hospital, London.
Eye (London, England)
|January 1, 1989
Summary
Corneal grafts larger than 10mm saved most eyes with infections or perforations, restoring useful vision. Despite complications like glaucoma and rejection, 13 eyes maintained clear grafts after treatment.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Transplantation Surgery
Background:
- Corneal infections and perforations pose significant threats to vision.
- Large-diameter corneal grafts are crucial for restoring ocular integrity and function in severe cases.
- Graft survival and visual outcomes are critical metrics in corneal transplantation.
Purpose of the Study:
- To evaluate the efficacy and outcomes of large-diameter corneal grafting (≥10 mm) in eyes with infections or perforations.
- To assess the long-term graft survival rate and visual acuity following the procedure.
- To identify and describe the management of complications associated with large corneal grafts.
Main Methods:
- A retrospective analysis of 17 large-diameter corneal grafts (≥10 mm) in 16 eyes of 15 patients.
- Surgical indications included severe corneal infections or perforations.
- Follow-up ranged from 8 to 54 months (mean 26.4 months).
Main Results:
- The 4-year graft survival probability was 0.64.
- All but one eye were saved, with the majority regaining useful vision.
- Thirteen eyes had clear grafts at final review, including those requiring regrafting.
- Complications such as cataract, glaucoma, graft rejection, and infections were encountered and managed.
Conclusions:
- Large-diameter corneal grafting is a viable option for eyes with severe infections or perforations.
- While complications can occur, effective management strategies contribute to favorable long-term outcomes.
- Close patient-medical team cooperation is essential for successful corneal graft survival and visual rehabilitation.