Elemanolide dimers from seeds of Vernonia anthelmintica
Ablajan Turak1, Yongqiang Liu2, Haji Akber Aisa2
1The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of the Chinese Academy of Sciences, Beijing 100039, China.
Abstract:
The seeds of Vernonia anthelmintica afforded three new elemanolide dimers, vernodalidimers C, D, and E, and four known elemanolides. Their structures were elucidated based on extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations of the new dimers were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolated compounds against four human tumor cell lines was assayed. Vernodalidimers C, D, and E exhibited strong cytotoxicity against T47D cell line with IC50 values of 5.58, 0.95, and 12.75μM, respectively.
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