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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
Published on: June 11, 2017
Mechanism and mortality of pediatric aortic injuries
Jun Tashiro1, William M Hannay1, Charlene Naves1
1Division of Pediatric Surgery, University of Miami, Miami, Florida.
Insights
Pediatric aortic injuries, often from motor vehicle accidents, have a 65% survival rate. Factors like gender, race, insurance, income, and hospital type significantly impact survival outcomes in children and adolescents.
Area of Science:
- Pediatric Trauma Surgery
- Vascular Injury Research
- Public Health Surveillance
Background:
- Aortic injuries in children and adolescents are rare but carry a high mortality rate.
- Understanding injury mechanisms and survival predictors is crucial for this vulnerable population.
Purpose of the Study:
- To investigate the primary mechanisms of aortic injury in pediatric patients.
- To identify key predictors of in-hospital mortality for thoracic and abdominal aortic injuries in individuals under 20 years old.
Main Methods:
- Utilized the Kids' Inpatient Database (1997-2009) to identify pediatric cases of aortic injury.
- Employed bivariate and risk-adjusted multivariate analyses to assess associated diagnoses, procedures, and mortality predictors.
- Included only emergent or urgent admissions for analysis.
Main Results:
- Identified 468 cases with an overall survival rate of 65%. Motor vehicle accidents were the leading cause (77%).
- Multivariate analysis revealed lower mortality in boys, Hispanic children, those in higher income quartiles, and patients at urban non-teaching hospitals.
- Traumatic shock and exploratory laparotomy were associated with the highest mortality; survival improved from 1997 to 2009.
Conclusions:
- Motor vehicle incidents are the predominant cause of pediatric aortic injuries.
- Gender, race, payer status, income, and hospital type are significant determinants of mortality.
- Associated diagnoses and procedures critically influence survival outcomes in pediatric aortic injury cases.
Background:
Aortic injuries are rare, but have a high mortality rate in children and adolescents. We sought to investigate mechanisms of injury and predictors of survival.
Materials And Methods:
The Kids' Inpatient Database (1997-2009) was used to identify cases of thoracic and abdominal aortic injury (International Classification of Diseases, ninth Revision, Clinical Modification codes 901.0, 902.0) occurring in children aged <20 y. Bivariate and risk-adjusted multivariate analyses were used to reveal associated diagnoses and procedures and to identify predictors of in-hospital mortality, respectively. Cases were limited to emergent or urgent admissions.
Results:
A total of 468 cases were identified. Survival was 65% overall, 63% for boys and 68% for girls. The most common mechanism of injury was motor vehicle-related (77%), followed by other penetrating trauma (10%) and firearm injury (8%). On multivariate modeling, boys (odds ratio, 0.15 [95% confidence interval, 0.05, 0.45]) and Hispanic children (0.17 [0.05, 0.60]) had lower associated mortality versus girls and Caucasians, respectively. Self-pay patients (6.47 [1.94, 21.6]) had higher mortality versus privately insured patients. Children in the fourth income quartile had lower mortality versus all income quartile patients. Patients admitted to urban nonteaching hospitals (0.15 [0.04, 0.59]) had lower mortality versus those admitted to urban teaching hospitals. Patients with traumatic shock (47.9 [12.3, 187]) or necessitating exploratory laparotomy (13.7 [2.06, 91.4]) had the highest associated mortality overall. Survival increased over the study period between 1997 and 2009.
Conclusions:
Motor vehicle-related injuries are the predominant mechanisms of aortic injury in the pediatric population. Gender, race, payer status, income quartile, and hospital type, along with associated procedures and diagnoses, are significant determinants of mortality on multivariate analysis.
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