Related Experiment Video
Updated: Apr 14, 2026

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
Published on: October 11, 2018
Sleep in children with neurodevelopmental disabilities
Marco Angriman1, Barbara Caravale2, Luana Novelli2
1Department of Pediatrics, Child Neurology and Neurorehabilitation Unit, Central Hospital of Bolzano, Italy.
Insights
Children with neurodevelopmental disabilities (NDDs) frequently experience sleep disorders. This review covers research on pediatric NDD-associated sleep issues and their treatments to improve patient and family quality of life.
Area of Science:
- Pediatric Neurology
- Sleep Medicine
- Neurodevelopmental Disabilities
Background:
- Neurodevelopmental disabilities (NDDs) affect over 2% of children.
- Sleep problems are prevalent in children with NDDs, accounting for over 35% of referrals to neuropsychiatric centers.
- Sleep disorders significantly impact the quality of life for children with NDDs and their families.
Purpose of the Study:
- To review current research on pediatric sleep disorders linked to NDDs.
- To outline clinical and therapeutic strategies for managing these sleep issues.
- To discuss commonly used medications for sleep disorders in this population.
Main Methods:
- Comprehensive literature review of recent research.
- Analysis of clinical and therapeutic aspects of sleep disorders in specific NDDs.
- Examination of pharmacological interventions for pediatric NDD-related sleep problems.
Main Results:
- Children with NDDs exhibit a high prevalence of sleep disorders.
- Specific sleep disorder characteristics and treatments are detailed for conditions including Down syndrome, Fragile X syndrome, autism spectrum disorders, and others.
- Commonly prescribed medications for sleep in children with NDDs are identified.
Conclusions:
- Pediatric sleep disorders are a significant concern in neurodevelopmental disabilities.
- An tailored clinical and therapeutic approach is essential for managing sleep problems in children with NDDs.
- Effective management of sleep disorders can substantially enhance the well-being of affected children and their families.
Abstract:
This review describes recent research in pediatric sleep disorders associated with neurodevelopmental disabilities (NDDs) and their treatment. NDDs affect more than 2% of the general population and represent more than 35% of the total cases of children referred to a neuropsychiatric center for sleep problems. Specific clinical and therapeutic aspects of sleep disorders associated with Down syndrome, Fragile X syndrome, Prader-Willi syndrome, Angelman syndrome, Rett syndrome, Smith-Magenis syndrome, cerebral palsy, and autism spectrum disorders are described. Furthermore, the drugs commonly used for sleep disorders in children with NDDs are described. The review clearly highlighted that children with NDDs are often affected by sleep disorders that require appropriate clinical and therapeutic approach to improve quality of life in both patients and families.
Related Concept Videos
REM Sleep Behavior Disorder
RBD is significantly associated with...
Nightmares and Night Terrors
Nightmares...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Learning Disabilities
Dyslexia
Dyslexia is a...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Intellectual Disability

