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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Acute Coronary Syndrome IV: Interprofessional Care01:28

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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
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Interventions for rosacea.

Esther J van Zuuren1, Zbys Fedorowicz, Ben Carter

  • 1Department of Dermatology, Leiden University Medical Center, PO Box 9600, B1-Q, Leiden, Netherlands, 2300 RC.

The Cochrane Database of Systematic Reviews
|April 29, 2015
PubMed
Summary
This summary is machine-generated.

This review found high-quality evidence supporting topical azelaic acid, ivermectin, brimonidine, doxycycline, and isotretinoin for rosacea treatment. Moderate evidence supports metronidazole and tetracycline, while low evidence supports minocycline, laser, and light therapies.

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Area of Science:

  • Dermatology
  • Evidence-based medicine
  • Systematic review

Background:

  • Rosacea is a common chronic facial skin condition with symptoms including redness, pimples, and dilated blood vessels.
  • Ocular involvement and skin thickening (phymas) can occur in some rosacea patients.
  • Current treatment options exist, but their comparative effectiveness remains unclear.

Purpose of the Study:

  • To systematically assess the efficacy and safety of various treatments for rosacea.
  • To provide evidence-based guidance on the most effective rosacea therapies.

Main Methods:

  • Conducted an updated systematic review of randomized controlled trials (RCTs) up to July 2014.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, and Science Citation Index.
  • Included 106 RCTs involving 13,631 participants with moderate to severe rosacea.

Main Results:

  • High-quality evidence supports topical azelaic acid, ivermectin, brimonidine, oral doxycycline, and oral isotretinoin for rosacea.
  • Moderate-quality evidence supports topical metronidazole and oral tetracycline.
  • Topical brimonidine effectively reduced facial erythema; topical ivermectin showed superiority over metronidazole in one study.

Conclusions:

  • Several treatments, including topical azelaic acid, ivermectin, brimonidine, doxycycline, and isotretinoin, demonstrate effectiveness for rosacea.
  • Further research is needed to fully address treatment response times, remission durations, and ocular rosacea therapies.
  • Improved reporting of adverse events in future studies is recommended.