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Ovarian response biomarkers: physiology and performance
Stamatina Iliodromiti1, Scott M Nelson
1School of Medicine, University of Glasgow, Glasgow, Scotland, UK.
Current Opinion in Obstetrics & Gynecology
|April 29, 2015
Summary
Automated anti-Müllerian hormone (AMH) assays offer accurate ovarian response prediction. AMH is superior to antral follicle count (AFC) for personalized fertility treatments, making follicle counting less relevant.
Area of Science:
- Reproductive Endocrinology
- Clinical Chemistry
Background:
- Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) are key markers for assessing ovarian reserve.
- Technological advancements are crucial for improving the accuracy and reliability of these measurements.
Purpose of the Study:
- To review recent technological developments in AMH measurement.
- To update the comparative performance of AMH and AFC in predicting ovarian response to controlled stimulation.
Main Methods:
- Review of technological advancements in AMH immunoassays.
- Analysis of comparative studies on AMH and AFC for ovarian response prediction.
Main Results:
- Automated AMH immunoassays have overcome limitations of manual assays, providing consistent and accurate results.
- New reference ranges and clinical thresholds are needed due to different calibration of automated assays.
- Randomized controlled trials demonstrate AMH's superiority over AFC in predicting ovarian response.
Conclusions:
- Future ovarian response prediction will be primarily AMH-focused, supported by automated assay technology.
- While sonography remains vital for diagnosing gynecological pathologies, antral follicle counting is becoming obsolete.
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