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Updated: Apr 14, 2026

Quantitative Assessment Protocol for Facial Soft Tissue Volumetric Changes with Stereophotogrammetry
Published on: December 9, 2025
Pertinent anatomy and analysis for midface volumizing procedures.
Christopher C Surek1, Javier Beut, Robert Stephens
1Kansas City, Kan.; New York, N.Y.; Independence, Mo.; and Palma de Mallorca, Spain From the Department of Plastic Surgery, University of Kansas Medical Center; the Department of Anatomy, Kansas City University of Medicine and Biosciences; the Department of Plastic and Reconstructive Surgery, New York University; private practice; and Instituto Dr. Beut.
This study developed a safe, anatomically based midfacial analysis for nonsurgical rejuvenation. It identifies key injection zones and potential adverse event areas for precise facial contouring.
Area of Science:
- Anatomy
- Aesthetics
- Facial Rejuvenation
Background:
- Nonsurgical midfacial rejuvenation requires precise anatomical understanding.
- Current techniques lack standardized, anatomically derived guidelines for safe and effective injections.
Purpose of the Study:
- To create an anatomically inspired midfacial analysis for safe and accurate nonsurgical rejuvenation.
- To define specific injection target areas and identify zones associated with adverse events.
Main Methods:
- Dissection of twelve fresh hemifacial cadavers.
- Layered dissection to measure distances between midfacial fat compartments, prezygomatic space, mimetic muscles, and neurovascular bundles.
- Development of a topographic analysis for clinical injection guidance.
Main Results:
- A longitudinal line partitions the cheek into aesthetic regions, aiding in defining injection points.
- A six-step analysis identifies three target zones and two adverse event zones.
- Specific anatomical landmarks correlate with potential complications like jowling and infraorbital artery injury.
Conclusions:
- The developed stepwise analysis provides a reproducible method for identifying midfacial target and adverse event zones.
- This approach enhances safety and accuracy in nonsurgical midface volumizing procedures.
- The method supports both procedural application and record-keeping for consistent outcomes.
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