Related Experiment Video
Updated: Apr 14, 2026

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
North American Prodrome Longitudinal Study (NAPLS 2): The Prodromal Symptoms
Jean Addington1, Lu Liu, Lisa Buchy
1*Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; †Department of Psychiatry, UCSD, La Jolla, CA; ‡Department of Psychology, Yale University, New Haven, CT; §Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY; ∥Department of Psychiatry, University of North Carolina, Chapel Hill, NC; ¶Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, MA; #Departments of Psychology and Psychiatry, Emory University, Atlanta, GA; **Department of Psychiatry, Yale University, New Haven, CT; ††Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles; and ‡‡Department of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, CA.
Abstract:
In studies describing the long-term follow-up up of youth at clinical high risk (CHR) of psychosis, little attention has been given to details of specific prodromal symptoms. In this paper, we describe the prodromal symptoms of 764 CHR participants recruited in the multi-site North American Prodrome Longitudinal Study (NAPLS). Symptoms were rated on the Scale of Prodromal Symptoms (SOPS) at baseline and 6-, 12-, 18-, and 24-month follow-ups. Clinical outcome at the 2-year assessment was categorized as psychotic, prodromal progression, symptomatic or in remission. Most of the CHR sample (92%) met criteria for the attenuated positive symptoms syndrome (APSS). Significant improvements in SOPS symptoms were observed over time. Unusual thought content, disorganized communication, and overall ratings on disorganized symptoms differentiated those who transitioned to psychosis from the other clinical outcome groups. Suspiciousness and total positive symptoms differentiated those in remission from the other clinical outcome groups.
More Related Videos
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Related Concept Videos
Longitudinal Research
Longitudinal Studies
Investigation of Disease Outbreaks
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
Introduction to Epidemiology
Acute Coronary Syndrome III: Diagnostic Studies