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Updated: Apr 14, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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Exosomes are unlikely involved in intercellular Nef transfer.

Xiaoyu Luo1, Yan Fan1, In-Woo Park1

  • 1Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, 76107, United States of America.

Plos One
|April 29, 2015
PubMed
Summary

Intercellular transfer of HIV-1 Nef protein to neighboring cells is crucial for HIV/AIDS pathogenesis. This study demonstrates Nef transfer is cell-contact dependent and unlikely involves exosomes, revealing two distinct exosome types.

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