Related Experiment Videos
Twenty-five loci form a continuous linkage map of markers for human chromosome 7
G M Lathrop1, P O'Connell, M Leppert
1Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132.
Genomics
|November 1, 1989
Abstract:
We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease.