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Related Experiment Videos

Intracellular localization of cerium. A microanalytical study using an electron microprobe and ionic microanalysis.

J P Berry1, R Masse, F Escaig

  • 1Service Commun 27 de l'Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine 8., Creteil, France.

Human Toxicology
|November 1, 1989
PubMed
Summary

Radioactive cerium is a nuclear toxicant. Ionic microanalysis and electron microprobe revealed cerium

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Area of Science:

  • Environmental Science
  • Toxicology
  • Nuclear Chemistry

Background:

  • Radioactive cerium (Ce) is a nuclear toxicant with industrial applications.
  • Understanding its intracellular metabolism is crucial for radiological protection.

Purpose of the Study:

  • To investigate the intracellular metabolism and distribution of cerium in rats.
  • To determine the sites of cerium incorporation and concentration in various tissues.

Main Methods:

  • Intraperitoneal injection and aerosol exposure of cerium in rats.
  • Utilized electron microprobe and ionic microanalysis for microanalysis.
  • Achieved high sensitivity detection with spatial resolution down to 0.5 microns.

Main Results:

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  • Identified lysosomal localization of cerium in liver, lung, kidney, bone marrow, and bone tissue.
  • Demonstrated coprecipitation of cerium with phosphorus within lysosomes.
  • Ionic analysis detected very low cerium concentrations.

Conclusions:

  • Cerium's intracellular metabolism involves lysosomal incorporation and phosphorus coprecipitation.
  • Findings are relevant for assessing and mitigating risks associated with cerium exposure.
  • Microanalytical techniques provide critical insights into toxicant distribution.