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Updated: Apr 13, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Cell-assisted lipotransfer.

Soraya Grabin¹, Gerd Antes, G Björn Stark

¹Department of Plastic Surgery, University Medical Center Freiburg, German Cochrane Centre, University Medical Center Freiburg, Center for Medical Biometry and Medical Informatics, University of Freiburg, Department of General and Visceral Surgery, University Medical Center Freiburg.

Deutsches Arzteblatt International

|April 30, 2015

Summary

This summary is machine-generated.

Cell-assisted lipotransfer using adipose-derived stem cells (ADSC) shows no proven benefit over conventional methods. Current evidence on the safety and efficacy of this novel stem cell treatment is insufficient for widespread clinical use.

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Area of Science:

Regenerative Medicine
Stem Cell Therapy
Plastic Surgery

Background:

Adipose-derived stem cells (ADSC) are accessible and possess versatile biological properties, making them attractive for clinical applications.
Cell-assisted lipotransfer, involving ADSC addition to fatty tissue, is a novel procedure gaining rapid clinical and commercial promotion.
There is a lack of clear clinical evidence regarding the safety and efficacy of cell-assisted lipotransfer.

Purpose of the Study:

To systematically review the existing clinical evidence on cell-assisted lipotransfer.
To assess the safety and efficacy of ADSC-enhanced lipotransfer compared to conventional autologous lipotransfer.

Main Methods:

A systematic literature search was conducted according to PRISMA criteria across eight major medical databases.
Publications were screened by title, abstract, and full text by two independent reviewers.
Clinical studies were assessed using objective criteria for evidence quality.

Main Results:

Out of 3161 retrieved publications, 13 clinical studies were relevant, with only 3 meeting grade II or III evidence criteria.
The analyzed studies included 286 cell-assisted lipotransfer procedures with a maximum follow-up of 42 months.
Oncological safety of cell-assisted lipotransfer was not demonstrated in the reviewed studies.

Conclusions:

Current studies do not demonstrate that cell-assisted lipotransfer is superior to conventional autologous lipotransfer.
The safety aspects of cell-assisted lipotransfer have been inadequately addressed in existing literature.
High-quality clinical evidence is essential before implementing novel stem cell treatments like cell-assisted lipotransfer.