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New insights into the mechanisms of diastolic dysfunction in patients with type 2 diabetes

Al Bayraktar1, Uğur Canpolat, Edis Demiri

  • 1Cardiology Clinic, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital , Trabzon , Turkey.

Scandinavian Cardiovascular Journal : SCJ
|April 30, 2015
PubMed
Abstract

Insights

Serum soluble RAGE (sRAGE) levels are lower in type 2 diabetes patients and linked to diastolic dysfunction. Lower sRAGE indicates higher risk for diabetic cardiovascular complications.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • The role of advanced glycation end products (AGEs) and their receptor (RAGE) in diabetic cardiovascular complications remains largely unknown.
  • Investigating the association between serum soluble RAGE (sRAGE) and left ventricular (LV) diastolic dysfunction in type 2 diabetes is crucial.

Purpose of the Study:

  • To evaluate the association between serum sRAGE levels and left ventricular diastolic dysfunction in patients with type 2 diabetes.
  • To explore the correlation of sRAGE with diabetes duration and diastolic dysfunction parameters.

Main Methods:

  • A study involving 40 type 2 diabetes patients and 40 age/sex-matched healthy controls.
  • Exclusion criteria included age ≥ 50 years and existing cardiovascular risk factors.
  • Serum sRAGE levels were measured using enzyme-linked immunosorbent assay; LV diastolic dysfunction was assessed per American Society of Echocardiography guidelines.

Main Results:

  • Serum sRAGE levels were significantly lower in the diabetic group compared to controls (676 ± 128 vs. 1044 ± 344, p < 0.05).
  • Diastolic dysfunction was present in 50% of diabetic patients (40% grade I, 10% grade II).
  • Serum sRAGE negatively correlated with diabetes duration and LV diastolic function parameters (septal E'/A', lateral E'/A', average E/E'); it was strongly associated with diastolic dysfunction in multivariate analysis.

Conclusions:

  • Serum sRAGE levels are significantly lower in type 2 diabetic patients under 50 years old.
  • sRAGE shows a negative correlation with diabetes duration.
  • Reduced serum sRAGE is significantly associated with the presence of diastolic dysfunction in type 2 diabetes.
Keywords:
diastolic dysfunctionsRAGEtype 2 diabetes

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