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Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
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[Enthesitis in connection with spondyloarthritides].
1Rheumatologie, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Deutschland, hildrun.haibel@charite.de.
Der Orthopade
|April 30, 2015
Summary
Enthesitis, a common symptom in spondyloarthritis and psoriatic arthritis, affects up to 40% of patients. While treatments like NSAIDs and corticosteroids are used, tumor necrosis factor alpha blockers show high efficacy in clinical trials.
Area of Science:
- Rheumatology
- Immunology
Context:
- Enthesitis is a key feature in spondyloarthritis (SpA) and psoriatic arthritis (PsA), impacting up to 40% of SpA patients.
- It is a defining criterion in classification for SpA and PsA, commonly affecting the heel.
- Differential diagnoses, including mechanical-degenerative causes and fibromyalgia, must be excluded during diagnosis.
Purpose:
- To review the role of enthesitis in SpA and PsA.
- To discuss diagnostic methods and therapeutic options for enthesitis.
- To highlight the efficacy of TNF-alpha blockers in managing enthesitis.
Summary:
- Enthesitis is prevalent in SpA and PsA, influencing classification criteria.
- Power Doppler ultrasound (PDUS) and MRI are crucial for diagnosis.
- Current treatments include NSAIDs and corticosteroids, with limited DMARD efficacy, but TNF-alpha blockers demonstrate significant effectiveness.
Impact:
- Provides a comprehensive overview of enthesitis in SpA and PsA.
- Emphasizes the diagnostic utility of advanced imaging techniques.
- Underscores the therapeutic potential of TNF-alpha inhibitors for enthesitis management.
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