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Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer

Claire M Perks1, Jeff Mp Holly

  • 1IGF & Metabolic Endocrinology Group, School of Clinical Sciences, University of Bristol, Learning and Research Building, Southmead Hospital, Bristol, BS10 5NB, UK, claire.m.perks@bristol.ac.uk.

Journal of Cell Communication and Signaling
|April 30, 2015
PubMed

Insights

Epigenetic alterations in cancer disrupt gene expression. This review focuses on the epigenetic regulation of insulin-like growth factor binding protein 3 (IGFBP-3) in cancer development and progression.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetics involves heritable gene expression changes without altering DNA sequence.
  • Disrupted epigenetic mechanisms are crucial in cancer pathogenesis, leading to malignant transformation.
  • Non-coding RNAs, DNA methylation, and histone modifications are key epigenetic regulators.

Purpose of the Study:

  • To review the epigenetic regulation of Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) in cancer.
  • To highlight the role of the IGF axis in cancer development and progression.
  • To focus on IGFBP-3 due to frequent alterations in tumor genes.

Main Methods:

  • Literature review of epigenetic mechanisms affecting IGFBP-3.
  • Analysis of studies on DNA methylation, histone modifications, and non-coding RNAs impacting IGFBP-3.
  • Examination of the role of the IGF axis in cancer.

Main Results:

  • IGFBP genes are frequently altered in tumors.
  • Epigenetic dysregulation of IGFBP-3 is implicated in cancer.
  • The IGF axis is a significant factor in cancer progression.

Conclusions:

  • Epigenetic regulation of IGFBP-3 is a critical aspect of cancer development.
  • Understanding these mechanisms offers potential therapeutic targets.
  • Further research into IGFBP-3 epigenetic modifications is warranted.

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