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Impulse response method for characterization of echogenic liposomes.

Jason L Raymond1, Ying Luan2, Tom van Rooij2

  • 1Biomedical Engineering Program, University of Cincinnati, Cardiovascular Center 3940, 231 Albert Sabin Way, Cincinnati, Ohio 45267-0586.

The Journal of the Acoustical Society of America
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces an optical method to measure the damping of air-filled ultrasound contrast agents (UCAs). The research quantifies shell viscosity in echogenic liposomes (ELIPs), revealing shear-thinning behavior consistent with other UCAs.

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Area of Science:

  • Acoustics and Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Ultrasound contrast agents (UCAs) are crucial for diagnostic imaging.
  • Characterizing the shell properties of UCAs, such as viscosity, is vital for understanding their acoustic behavior.
  • Previous methods for UCA characterization have limitations in individual microbubble analysis.

Purpose of the Study:

  • To develop and validate an optical characterization method for assessing the damping properties of air-filled UCAs.
  • To estimate the interfacial shell viscosity of individual echogenic liposomes (ELIPs) using their impulse response.
  • To investigate the relationship between shell viscosity and dilatation rate in ELIPs.

Main Methods:

  • Utilized an impulse response technique to analyze the unforced decaying response of individual ELIPs.
  • Employed ultra-high-speed camera recordings to optically measure the radius versus time response.
  • Applied broadband acoustic impulse excitation to elicit responses from individual microbubbles.

Main Results:

  • Successfully measured the radius versus time response of 106 individual ELIPs.
  • Observed a decrease in shell viscosity with increasing dilatation rate, consistent with rheological shear-thinning.
  • Quantitatively validated the measured shell viscosity against previously reported values for ELIPs and other lipid-shelled UCAs.

Conclusions:

  • The presented optical method provides an efficient and accurate means to estimate shell viscosity and damping for individual UCA microbubbles.
  • Air-filled ELIPs exhibit acoustic responses similar to perfluorocarbon-filled UCAs, suggesting broader applicability.
  • The findings contribute to a deeper understanding of UCA mechanics and their potential in ultrasound imaging.