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Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
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Primary cervical ganglioneuroblastoma
Joseph G Manjaly1, Victoria R C Alexander1, Christopher M Pepper1
1Department of ENT, Great Ormond Street Hospital, London, United Kingdom.
International Journal of Pediatric Otorhinolaryngology
|April 30, 2015
Summary
Ganglioneuroblastomas are rare tumors that can be misdiagnosed based on imaging alone. Biopsy is crucial for accurate diagnosis of these pediatric neck masses.
Area of Science:
- Pediatric Oncology
- Surgical Pathology
Background:
- Ganglioneuroblastomas are a rare histological subtype of neuroblastic tumors with intermediate malignant potential.
- These tumors originate from neural crest progenitor cells in sympathetic nerves.
Observation:
- This study reviewed 4 pediatric cases presenting with solitary neck masses at Great Ormond Street Hospital.
- Initial imaging diagnoses included lymphatic malformation, carotid body tumor, and paraganglioma in three cases.
- One case was correctly diagnosed via incisional biopsy.
Findings:
- The mean age of presentation was 5 years.
- All 4 cases were successfully managed with surgical excision.
- No recurrence was observed after a median follow-up of 6 years.
Implications:
- Otolaryngologists should consider ganglioneuroblastoma in the differential diagnosis of pediatric neck masses.
- Histopathological examination via biopsy is essential for accurate diagnosis, preventing misdiagnosis.
- Early and accurate diagnosis facilitates effective surgical management and favorable outcomes.
Keywords:
Cervical massGanglioneuroblastomaNeuroblastic tumourNeuroblastomaPaediatricParapharyngeal spaceMore Related Videos
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