ICD and CRT use in ischemic heart disease in women

Area of Science:

• Cardiology
• Medical Devices
• Women's Health

Background:

• Implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) improve outcomes in ischemic cardiomyopathy (ICM).
• Existing literature on gender-based survival outcomes in ICM is limited.
• Women with cardiomyopathy more frequently have non-ischemic cardiomyopathy (NICM).

Purpose of the Study:

• To review the current literature on prognosis, pathophysiology, and clinical practice for device implantation in women with ICM.
• To highlight the limited data on gender-based survival outcomes in ICM.
• To provide a comprehensive overview for clinicians managing female patients with ICM.

Main Methods:

• Systematic literature review.
• Analysis of existing studies on device therapy in ICM.
• Synthesis of data on prognosis and pathophysiology in women with ICM.

Main Results:

• Data on gender-specific survival outcomes for ICD and CRT in ICM are scarce.
• Most available data are derived from sub-study analyses.
• Non-ischemic cardiomyopathy (NICM) is more prevalent in women.

Conclusions:

• Further research is needed to understand gender-based differences in ICM outcomes with device therapy.
• Clinical practice for device implantation in women with ICM requires careful consideration of limited evidence.
• A comprehensive understanding of ICM in women is crucial for optimizing treatment strategies.