Proteus syndrome: what the anesthetist should know

Area of Science:

• Medical Science
• Genetics
• Anesthesiology

Background:

• Proteus syndrome (PS) is a rare congenital hamartomatous disorder characterized by mosaic overgrowth.
• The complex and variable nature of PS presents significant challenges in perioperative management.
• Understanding the anesthetic implications is crucial for patient safety.

Observation:

• A 14-year-old male patient diagnosed with Proteus syndrome underwent corrective osteotomy of the right knee.
• The surgical procedure was performed under subarachnoid block anesthesia.
• This case highlights specific considerations for anesthetists managing PS patients.

Findings:

• The case demonstrates the successful application of subarachnoid block in a patient with Proteus syndrome.
• Key anesthetic considerations for patients with PS were identified and are discussed.
• Perioperative care requires a tailored approach due to the syndrome's multifaceted presentation.

Implications:

• Anesthetists require specialized knowledge to manage the unique perioperative risks associated with Proteus syndrome.
• This case report serves as an educational resource for clinicians.
• Improved understanding can lead to safer anesthetic practices for individuals with rare genetic disorders like PS.