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Related Experiment Video

Updated: Apr 13, 2026

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants &#8212; Buried Food and Social Odor Tests
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Chronic stress impacts on olfactory system.

Ti-Fei Yuan, Gonglin Hou, Oscar Arias-Carrion1

  • 1School of Psychology, Nanjing Normal University, Nanjing, China. ytf0707@126.com.

CNS & Neurological Disorders Drug Targets
|April 30, 2015
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Summary
This summary is machine-generated.

Chronic stress damages brain function, including the olfactory system, leading to olfactory deficits. Therapies targeting the sense of smell may help treat stress-related neurological diseases.

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Area of Science:

  • Neuroscience
  • Stress Research
  • Olfactory System

Background:

  • Chronic stress negatively impacts brain structures and functions.
  • Previous research primarily examined prefrontal cortex and hippocampus.
  • Emerging evidence links stress to olfactory system changes and deficits.

Purpose of the Study:

  • To review evidence connecting chronic stress and olfactory system neuropathology.
  • To analyze potential mechanisms behind stress-induced olfactory changes.
  • To explore olfactory system-targeting therapies for stress-related disorders.

Main Methods:

  • Literature review of studies on chronic stress and the olfactory system.
  • Analysis of neuropathological changes in olfactory structures.
  • Examination of mechanistic insights and therapeutic potentials.

Main Results:

  • Chronic stress induces neuropathology in the olfactory system.
  • Olfactory deficits are observed in animal models and human depression.
  • Mechanisms linking stress to olfactory dysfunction are explored.

Conclusions:

  • Chronic stress significantly affects the olfactory system.
  • Olfactory deficits are a potential biomarker for stress-related conditions.
  • Targeting the olfactory system may offer novel therapeutic strategies for neurological diseases associated with stress.