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Related Concept Videos

Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Classification of Bones01:18

Classification of Bones

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The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
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Gross Anatomy of Bone01:17

Gross Anatomy of Bone

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The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Related Experiment Video

Updated: Apr 13, 2026

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Trabecular Bone Score: Where are we now?

Valérie Bousson1, Catherine Bergot2, Bruno Sutter3

  • 1Radiologie ostéo-articulaire, université Paris VII-Denis-Diderot, Sorbonne Paris Cité, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France; B2OA, CNRS UMR 7052, 10, avenue de Verdun, 75010 Paris, France.

Joint Bone Spine
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

Trabecular Bone Score (TBS) is a novel index reflecting bone microarchitecture. While TBS can identify fracture risk and is reduced in patients with fragility fractures, it is not recommended for monitoring osteoporosis treatments.

Keywords:
Bone mineral densityDensitometryFragility fractureOsteoporosisTrabecular Bone Score

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Assessment of Bone Fracture Healing Using Micro-Computed Tomography
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Area of Science:

  • Osteoporosis research
  • Bone densitometry
  • Radiology

Background:

  • Trabecular Bone Score (TBS) is a recent index assessing bone microarchitecture from DXA scans.
  • It is proposed as a surrogate for bone strength, aiding clinical practice.

Purpose of the Study:

  • To review technical aspects of TBS, including correlations with microarchitecture and strength.
  • To evaluate TBS's efficacy in fracture prediction and treatment monitoring.

Main Methods:

  • Systematic review of studies correlating TBS with bone microarchitecture, strength, and clinical outcomes.
  • Analysis of factors influencing TBS, such as age, BMI, and osteoarthritis.
  • Assessment of TBS's performance in distinguishing fracture patients and predicting future fractures.

Main Results:

  • TBS correlations with microarchitecture vary significantly and explain limited variance in vivo.
  • TBS is reduced in patients with fragility fractures and shows discriminative ability for fracture risk.
  • Combined analysis suggests TBS is a fracture predictor, but hip areal bone density remains superior in prospective studies.

Conclusions:

  • TBS is a texture parameter reflecting bone microarchitecture, useful for fracture risk assessment.
  • Current evidence does not support using TBS for monitoring patients undergoing anti-osteoporotic drug treatment.