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Effects of spatial memory on morphine CPP and locomotor sensitization in mice
Xiaolin Zhu1, Wei Sun2, Xinwang Li3
1Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing 100048, China; Center for Psychiatric Research, Beijing Huilongguan Hospital, Beijing 100096, China.
Physiology & Behavior
|April 30, 2015
Summary
Spatial memory retrieval ability influences morphine reward and psychomotor excitement in mice. Mice with lower spatial memory showed greater morphine-induced conditioned place preference and behavioral sensitization, suggesting memory
Area of Science:
- Neuroscience
- Behavioral Pharmacology
- Addiction Research
Background:
- Drug addiction is intricately linked with memory processes.
- Understanding how memory influences drug reward and seeking behavior is crucial for addiction research.
Purpose of the Study:
- To investigate the impact of spatial memory retrieval ability on morphine reward and psychomotor excitement.
- To explore the role of spatial memory in the development and expression of drug-induced behaviors.
Main Methods:
- Simultaneous measurement of conditioned place preference (CPP) and locomotor sensitization in mice.
- Mice were categorized into high and low spatial memory retrieval groups using the Morris water maze.
- Morphine administration (10mg/kg) was used to assess reward and sensitization.
Main Results:
- Morphine induced significant CPP in both high and low spatial memory groups, with a greater response in the low memory group.
- Locomotor activity during the expression phase of behavioral sensitization was significantly higher in low memory mice compared to high memory mice.
- No significant group-by-day interaction was observed during the development of behavioral sensitization.
Conclusions:
- Spatial memory retrieval ability significantly influences morphine-induced conditioned place preference and behavioral sensitization.
- These findings suggest that spatial memory processes may play a role in the pathophysiology of drug addiction.
- Targeting memory-related mechanisms could offer novel therapeutic strategies for addiction treatment.
