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Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway

Shingo Takeuchi1, Hironori Katoh1, Manabu Negishi2

  • 1Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Journal of Biochemistry
|April 30, 2015
PubMed
Summary

Eph/ephrin reverse signaling hinders axonal growth in neurons. This process involves the RhoA/ROCK pathway, impacting neuronal development and potentially neurological disorders.

Keywords:
EphROCKRhoAaxonal retractionephrin reverse signallinghippocampal neuron

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